产品名称：Anti-MGLUR3/FITC抗体

Anti-MGLUR3/FITC抗体

产品编号YB1237R-FITC

英文名称Anti-MGLUR3/FITC

中文名称FITC标记的代谢型谷氨酸受体-3抗体

别    名G protein coupled receptor family C group 1 member C; GLUR 3; GLUR3; GLUR3; Glutamate metabotropic receptor 3; Glutamate receptor metabotropic 3; GPRC1C; GRM 3; GRM3; GRM3_HUMAN; Metabotropic glutamate receptor 3; Metabotropic glutamate receptor 3 precursor; mGlu 3; MGlu3; MGlu3; MGLUR 3; MGLUR3.  

Anti-MGLUR3/FITC抗体

说 明 书100ul  

研究领域**学  信号转导  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量97kDa

Anti-MGLUR3/FITC抗体细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human GRM3

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-MGLUR3/FITC抗体产品介绍background:

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Function:

Receptor for glutamate.Anti-MGLUR3/FITC抗体 The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.

Subunit:

Interacts with GRASP.

Subcellular Location:

Cell membrane; Multi-pass membrane protein.

Similarity:

Belongs to the G-protein coupled receptor 3 family.

Database links:

Entrez Gene: 2913 Human

Entrez Gene: 108069 Mouse

Entrez Gene: 24416 Rat

Omim: 601115 Human

SwissProt: Q14832 Human

SwissProt: Q9QYS2 Mouse

SwissProt: P31422 Rat

Unigene: 590575 Human

Unigene: 318966 Mouse

Unigene: 41715 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GRM 3谷氨酸受体-代谢能3；主要参与细胞信号转导及突触传递，在G蛋白偶联受体蛋白信号转导途径中有一定的作用，并且有负调控腺苷酸环化酶的作用，为膜性蛋白，在胞膜、胞浆中表达。