产品名称：Anti-Metabotropic glutamate receptor 2/FITC抗体

Anti-Metabotropic glutamate receptor 2/FITC抗体

产品编号YB1161R-FITC

英文名称Anti-Metabotropic glutamate receptor 2/FITC

中文名称FITC标记的促代谢型谷氨酸受体2抗体

别    名Metabotropic Glutamate Receptor 2; Glutamate Receptor Metabotropic 2; Gprc1b; AMPA selective glutamate receptor 2; GLUR 2; GLUR2; GLURB; Glutamate receptor metabotropic 2; Metabotropic Glutamate Receptor 2; GPRC1B; GRM 2; Grm2; GRM2; mGlu 2; MGlu2; MGLUR 2; Mglur2; GRM2_HUMAN.  

Anti-Metabotropic glutamate receptor 2/FITC抗体

说 明 书100ul  

研究领域肿瘤  **学  信号转导  细胞凋亡  G蛋白偶联受体  G蛋白信号  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Cow, Horse,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量96kDa

细胞定位细胞膜

Anti-Metabotropic glutamate receptor 2/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human GRM2

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Metabotropic glutamate receptor 2/FITC抗体

产品介绍background:

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Function:

Receptor for glutamate. Anti-Metabotropic glutamate receptor 2/FITC抗体The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.

Subunit:

Interacts with GRASP.

Subcellular Location:

Cell membrane; Multi-pass membrane protein.

Tissue Specificity:

Widely expressed in different regions of the ***** brain as well as in fetal brain.

Similarity:

Belongs to the G-protein coupled receptor 3 family.

Database links:

Entrez Gene: 2912 Human

Entrez Gene: 108068 Mouse

Entrez Gene: 24415 Rat

Omim: 604099 Human

SwissProt: Q14416 Human

SwissProt: Q14BI2 Mouse

SwissProt: P31421 Rat

Unigene: 121510 Human

Unigene: 410822 Mouse

Unigene: 424639 Mouse

Unigene: 9681 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

谷氨酸受体-代谢能2；主要参与细胞信号转导及突触传递，在G蛋白偶联受体蛋白信号转导途径中有一定的作用，并且有负调控腺苷酸环化酶的作用，为膜性蛋白，在胞膜、胞浆中表达。