产品名称：Anti-GRK1/FITC抗体

Anti-GRK1/FITC抗体

产品编号YB-1082R-FITC

英文名称Anti-GRK1/FITC

中文名称FITC标记的G蛋白偶合受体激酶1抗体

别    名G-protein coupled receptor kinase 1; GRK1; GPRK1; RK; Grk1; Rhok; RHODOPSIN KINASE; RK_HUMAN.  

Anti-GRK1/FITC抗体

说 明 书100ul  

研究领域细胞生物  **学  神经生物学  信号转导  激酶和磷酸酶  细胞膜受体  G蛋白偶联受体  G蛋白信号  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Cow,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量62kDa

细胞定位细胞膜

Anti-GRK1/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human GRK1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-GRK1/FITC抗体

产品介绍background:

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq]

Function:

Phosphorylates rhodopsin thereby initiating its deactivation. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.

Subcellular Location:

Membrane.

Tissue Specificity:

Retina and pineal gland.

Post-translational modifications:

Autophosphorylated.

Farnesylation is required for full activity.

DISEASE:

Defects in GRK1 are a cause of congenital stationary night blindness Oguchi type 2 (CSNBO2) [MIM:613411]. It is non-progressive retinal disorder characterized by impaired night vision, often associatedAnti-GRK1/FITC抗体 with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation.

Similarity:

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

GPRK subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 protein kinase domain.

Contains 1 RGS domain.

Database links:

Entrez Gene: 6011 Human

Entrez Gene: 24013 Mouse

Omim: 180381 Human

SwissProt: Q15835 Human

SwissProt: Q9WVL4 Mouse

Unigene: 103501 Human

Unigene: 721727 Human

Unigene: 257501 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

G蛋白偶联受体激酶1(GRK1)是催化激动剂诱导的GPCR磷酸化以及启动GPCR**的关键激酶,主要用于GRK细胞膜转位和对GRK功能的影响.