产品名称：Anti-GLUT4/FITC抗体

Anti-GLUT4/FITC抗体

品编号YB-0384R-FITC

英文名称Anti-GLUT4/FITC

中文名称FITC标记的葡萄糖转运蛋白4抗体

别    名insulin-responsive; Glucose transporter GLUT 4; Glucose Transporter GLUT4; Glucose transporter type 4; Glucose transporter type 4 insulin responsive; GLUT 4; GLUT-4; GLUT4; GTR4_HUMAN; kug; SLC 2A4; SLC2A4; solute carrier family 2 (facilitated glucose transporter) member 4; Solute carrier family 2, facilitated glucose transporter member 4.  

Anti-GLUT4/FITC抗体

说 明 书100ul  

研究领域肿瘤  心血管  **学  信号转导  干细胞  糖尿病  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量54kDa

细胞定位细胞膜

Anti-GLUT4/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human GLUT4

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-GLUT4/FITC抗体

产品介绍background:

GLUT4 is the facilitated glucose transporter expressed exclusively in adipocytes and muscle cells, and is also known as the "insulin-responsive" glucose transporter. GLUT4 translocates from an ill-defined intracellular compartment to the plasma membrane in response to insulin. The total cellular content of GLUT4 is significantly decreased in adipose cells from many patients with Type II diabetes mellitus, and animals with some types of experimental diabetes.

Function:

Insulin-regulated facilitative glucose transporter.

Subcellular Location:

Endomembrane system. Cytoplasm > perinuclear region. Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. Anti-GLUT4/FITC抗体The dileucine internalization motif is critical for intracellular sequestration.

Tissue Specificity:

Skeletal and cardiac muscles; brown and white fat.

Post-translational modifications:

Sumoylated.

DISEASE:

Defects in SLC2A4 may be a cause of noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. Defects in SLC2A4 may be a cause of certain post-receptor defects in NIDDM. The variant in position Ile-383 is found in a small number of NIDDM patients, but seems not to be found in nondiabetic subjects.

Similarity:

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Database links:

Entrez Gene: 282359 Cow

Entrez Gene: 6517 Human

Entrez Gene: 20528 Mouse

Entrez Gene: 25139 Rat

Omim: 138190 Human

SwissProt: Q27994 Cow

SwissProt: Q29RP5 Cow

SwissProt: P14672 Human

SwissProt: P14142 Mouse

SwissProt: P19357 Rat

Unigene: 380691 Human

Unigene: 10661 Mouse

Unigene: 1314 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

葡萄糖转运蛋白-4是一种十分重要的葡萄糖转运体,与胰岛素抵抗和2型糖尿病密切相关.葡萄糖转运蛋白4在细胞内部和细胞膜之间循环流动.实现对葡萄糖的转运需要葡萄糖转运蛋白4自身的转位和活化.葡萄糖转运蛋白4与肥胖、肿瘤相关联.

GLUT-2和GLUT-4蛋白这两个葡萄糖运载体的研究对于糖尿病的胰岛素释放障碍和胰岛素抵抗有重要意