产品名称：Anti-GLUT3/FITC抗体

Anti-GLUT3/FITC抗体

产品编号YB1207R-FITC

英文名称Anti-GLUT3/FITC

中文名称FITC标记的葡萄糖转运蛋白3抗体

别    名brain; facilitated glucose transporter member 3; Glucose Transporter GLUT3 ; FLJ90380; Glucose Transporter Type 3; Glucose transporter type 3 brain; GLUT 3; GLUT-3; GLUT3; GTR3_HUMAN; SLC2A3; Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 3; Solute carrier family 2.  

Anti-GLUT3/FITC抗体

说 明 书100ul  

研究领域**学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,

产品应用Flow-Cyt=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量54kDa

细胞定位细胞膜

Anti-GLUT3/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human GLUT3

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-GLUT3/FITC抗体

产品介绍background:

may act as a glucose transporter in neurons; may mediate increasd glucose uptake in response to neuronal injury. Glucose is fundamental to the metabolism of mammalian cells. Several glucose transporter protein (Glut) isoforms have been identified and shown to function in response to insulin and IGF1 induced signaling. GLUT3 is detectable in a few normal cell type spermatids in testis with active spermatogenesis, placental trophoblast membranes, and neurons in brain. GLUT3 staining is also detectable in human cancers including those of the ovary, lung, and testis. Alternative names: FLJ90380; Glucose Transporter Type 3; Glucose transporter type 3 brain; GLUT 3; GLUT3; SLC2A3; Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 3.

Function:

Facilitative glucose transporter. Probably a neuronal glucose transporter.

Subcellular Location:

Cell membrane; Multi-pass membrane protein. Melanosome.

Tissue Specificity:

Highly expressed in brain.Anti-GLUT3/FITC抗体 Expressed in many tissues.

Similarity:

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Database links:

Entrez Gene: 6515 Human

Entrez Gene: 20527 Mouse

Entrez Gene: 25551 Rat

Omim: 138170 Human

SwissProt: P11169 Human

SwissProt: P32037 Mouse

SwissProt: Q07647 Rat

Unigene: 419240 Human

Unigene: 395108 Mouse

Unigene: 95055 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

交换和转运（Trafficking and Transport）

GLUT-3属于溶质运载蛋白家族成员（solute carrier family），主要功能是转载葡萄糖进入上皮细胞。

目前主要用于糖尿病肾病和视网膜病变的研究，也是肾小球系膜细胞上的主要葡萄糖转运体。GLUT3的功能状态直接影响系膜细胞的糖代谢及功能变化。

近期，研究人员也用来区别一些良、恶性肿瘤的鉴别。