产品名称：Anti-TNFRSF18/FITC抗体

Anti-TNFRSF18/FITC抗体

产品编号YB-1173R-FITC

英文名称Anti-TNFRSF18/FITC

中文名称FITC标记的糖皮质**诱导肿瘤坏死因子受体抗体

别    名Activation inducible TNFR family receptor; Activation-inducible TNFR family receptor; CD357; AITR; GITR; GITR D; GITR-D; GITRD; Glucocorticoid induced TNFR related protein; glucocorticoid-induced tnf receptor ligand; Glucocorticoid induced TNFR related protein; TNF receptor superfamily activation inducible protein; Glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation inducible protein; TNR18_HUMAN; TNFRSF 18; TNFRSF18; Tumor necrosis factor receptor superfamily member 18; Tumor necrosis factor receptor superfamily member 18 precursor.  

Anti-TNFRSF18/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  **学  生长因子和**  t-**细胞  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量24kDa

Anti-TNFRSF18/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human TNFRSF18

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-TNFRSF18/FITC抗体

产品介绍background:

TNFRSF18 or GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18) originally identified in the mouse by comparing untreated and dexamethasone-treated murine T cell hybridoma cells. Human GITR was subsequently identified by searching an expressed sequence tag database. GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR appears to be highly expressed on CD4+CD25+ T regulatory cells and has been shown to induce NF-kB activation through TRAF2/NIK signaling. GITR has been proposed to be involved in the development of regulatory T cells and to regulate the activity of Th1 subsets. GITR binds GITRL, a TNF superfamily ligand expressed on endothelial cells, dendritic cells, macrophages, and B cells.

Function:

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Anti-TNFRSF18/FITC抗体Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Subunit:

Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA.

Subcellular Location:

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Isoform 2: Secreted.

Tissue Specificity:

Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

Similarity:

Contains 3 TNFR-Cys repeats.

Database links:

Entrez Gene: 8784 Human

Entrez Gene: 21936 Mouse

Omim: 603905 Human

SwissProt: Q9Y5U5 Human

SwissProt: O35714 Mouse

Unigene: 212680 Human

Unigene: 3180 Mouse

Unigene: 482508 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.