产品名称：Anti-Ghrelin/FITC抗体

Anti-Ghrelin/FITC抗体

产品编号YB-0467R-FITC

英文名称Anti-Ghrelin/FITC

中文名称FITC标记的脑肠肽抗体

别    名Appetite regulating hormone; Ghrelin 27; Ghrelin 28; Ghrelin/obestatin prepropeptide; GHRL; Growth hormone releasing peptide; Growth hormone secretagogue; M46 protein; Motilin related peptide; MTLRP; Obestatin; Obestatin preprohormone; PRO1066; UNQ524; GHRL_HUMAN.  

Anti-Ghrelin/FITC抗体

说 明 书100ul  

研究领域心血管  神经生物学  信号转导  生长因子和**  糖尿病  新陈代谢  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量10kDa

Anti-Ghrelin/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Ghrelin

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Ghrelin/FITC抗体

产品介绍background:

This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression. [provided by RefSeq, Oct 2008].

Function:

Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.

Obestatin may be the ligand for GPR39.Anti-Ghrelin/FITC抗体 May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.

Subcellular Location:

Secreted.

Tissue Specificity:

Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.

Post-translational modifications:

O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid.

Amidation of Leu-98 is essential for obestatin activity.

Similarity:

Belongs to the motilin family.

Database links:

Entrez Gene: 51738 Human

Entrez Gene: 58991 Mouse

Entrez Gene: 59301 Rat

Entrez Gene: 574280 Rhesus monkey

Omim: 605353 Human

SwissProt: Q6BEG6 Cat

SwissProt: Q9BEF8 Dog

SwissProt: Q9UBU3 Human

SwissProt: Q9EQX0 Mouse

SwissProt: Q9GKY5 Pig

SwissProt: Q9QYH7 Rat

Unigene: 590080 Human

Unigene: 672979 Human

Unigene: 379095 Mouse

Unigene: 42103 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Ghrelin是近年来发现的一种内源性生长**促分泌剂受体的配体（一种新的生长**释放肽）。

广泛分布在人**神经系统(下丘脑、垂体)和消化系统(胃、肠、胰腺),并被发现拥有多种生物功能,如通过下丘脑刺激食欲、增加胃酸分泌、提高胃肠蠕动等.进而ghrelin和GHS-R在不同器官肿瘤组织中被发现,如垂体瘤、胃癌、肠癌、乳腺癌、甲状腺滤泡状癌,Ghrelin蛋白的种属同源性较高，人、大、小鼠、猪、羊、犬、牛都有存在。

大量研究证明ghrelin能影响不同肿瘤细胞的生长与增殖.其广泛的生物活性为今后肿瘤的诊断、**及预后的评估提供了新的研究方向.