产品名称：Anti-Gelsolin/FITC抗体

Anti-Gelsolin/FITC抗体

产品编号YB-1160R-FITC

英文名称Anti-Gelsolin/FITC

中文名称FITC标记的凝溶胶蛋白抗体

别    名Actin depolymerizing factor; ADF; AGEL; Amyloidosis Finnish type; Brevin; DKFZp313L0718; GSN; GELS_HUMAN; Actin-depolymerizing factor.  

Anti-Gelsolin/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  **学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量80kDa

Anti-Gelsolin/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Gelsolin

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Gelsolin/FITC抗体

产品介绍background:

Gelsolin is a calcium dependent actin binding protein. It is a potent modulator of actin filament length and gelation. Gelsolin has been shown to exist in at least two variant forms, cytoplasmic gelsolin and plasma gelsolin. Plasma gelsolin has also been called actin depolymerizing factor (ADF) or brevin. Human plasma and rabbit macrophage gelsolins differ by the presence of a 25 amino acid residue extension at the NH2 terminus in the human plasma gelsolin, which appears to account for the difference in relative molecular weights.

Function:

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.

Subunit:

Binds to actin and to fibronectin.Anti-Gelsolin/FITC抗体 Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X.

Subcellular Location:

Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted.

Tissue Specificity:

Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.

Post-translational modifications:

Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.

DISEASE:

Amyloidosis 5 (AMYL5) [MIM:105120]: A hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:

Belongs to the villin/gelsolin family.

Contains 6 gelsolin-like repeats.

Database links:

Entrez Gene: 2934 Human

Entrez Gene: 227753 Mouse

Entrez Gene: 296654 Rat

Omim: 137350 Human

SwissProt: P06396 Human

SwissProt: P13020 Mouse

SwissProt: Q68FP1 Rat

Unigene: 522373 Human

Unigene: 21109 Mouse

Unigene: 103770 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

凝溶胶蛋白(gelsolin)是凝溶胶蛋白超家族的成员之一,是一种重要的肌动蛋白结合蛋白,其通过切断、封端肌动蛋白丝,或使肌动蛋白聚集成核等方式来控制肌动蛋白的结构. 还在细胞运动、控制细胞程序性死亡等细胞活动中发挥重要的作用.此外,凝溶胶蛋白在肿瘤细胞中的表达量也发生一定的变化. gelsolin也参与细胞调节作用。