产品名称：Anti-Gax/FITC抗体

Anti-Gax/FITC抗体

产品编号YB-1250R-FITC

英文名称Anti-Gax/FITC

中文名称FITC标记的生长终止特异性同源盒基因抗体

别    名growth arrest-specific homeobox; Homeobox protein MOX-2; Mesenchyme homeobox 2; mesenchyme homeobox 2-like; Growth arrest-specific homeobox; GAX; growth arrest homeobox transcription factor GAX; mesenchyme homeobox 2; MEOX2_HUMAN.  

Anti-Gax/FITC抗体

说 明 书100ul  

研究领域肿瘤  心血管  **学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量33kDa

Anti-Gax/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Gax

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Gax/FITC抗体

产品介绍background:

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimers disease.

Function:

Role in mesoderm induction and its earliest regional specification,Anti-Gax/FITC抗体 somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity).

Subunit:

Interacts with RNF10.

Subcellular Location:

Nucleus. Nucleus speckle.

Similarity:

Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 4223 Human

Entrez Gene: 17286 Mouse

Entrez Gene: 29279 Rat

Omim: 600535 Human

SwissProt: P50222 Human

SwissProt: P32443 Mouse

SwissProt: P39020 Rat

Unigene: 170355 Human

Unigene: 341398 Mouse

Unigene: 34890 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Gax主要在血管平滑肌细胞和内皮细胞中表达的同源异形盒基因,但Gax基因过表达可以抑制血管平滑肌细胞和内皮细胞的增殖，Gax也是脊椎动物肢体发育的重要调节因子，目前除用于心血管方面的研究，也用于肿瘤血管方面的探索。