产品名称：Anti-Gastrin/FITC抗体

Anti-Gastrin/FITC抗体

产品编号YB1189R-FITC

英文名称Anti-Gastrin/FITC

中文名称FITC标记的胃泌素/蛙皮素抗体

别    名Gastrin component II; Gastrin-34; Gastrin 34; Gastrin34; G34; Gastrin component III; Gastrin-17; Gastrin 17; Gastrin17; G17; GAS; GAST; Gastrin precursor; Bombesin; gastrin big; Gastrin-71; Gastrin 71; Gastrin71; Gastrin-52; Gastrin 52; Gastrin52; Big gastrin; Gastrin-14; Gastrin 14; Gastrin14; G14; Gastrin-6; Gastrin 6; Gastrin6; G6; Gastrin; Gastrin component I; G52; GAST_HUMAN.  

Anti-Gastrin/FITC抗体

说 明 书100ul  

研究领域生长因子和**  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Pig, Rabbit,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量2.1/3.9/6/8kDa

Anti-Gastrin/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Gastrin

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Gastrin/FITC抗体

产品介绍background:

Gastrin is mainly known by its first described role as a gastric acid-hormone but the protein also has the ability to promote cellular growth. More recently, gastrin has been suggested to induce leukocyte-endothelial cell interactions and to have a pro-inflammatory effect. Gastrin has two biologically active peptide forms, G34 and G17 and they activate two different receptors: the CCK-1 receptor, which has low affinity for gastrin but high affinity for the related hormone cholecystokinin (CCK), and the CCK-2 receptor, which has high affinity for both gastrin and CCK and mediates the acid-secretory as well as the proliferative effects of gastrin.

Function:

Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

Subcellular Location:

Secreted.

Post-translational modifications:

Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17.Anti-Gastrin/FITC抗体In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.

Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.

Similarity:

Belongs to the gastrin/cholecystokinin family.

Database links:

Entrez Gene: 2520 Human

Entrez Gene: 14459 Mouse

Omim: 137250 Human

SwissProt: P01350 Human

SwissProt: P48757 Mouse

Unigene: 2681 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Gastrin又称蛙皮素（Bombesin），是一种含十七个氨基酸残基的多肽类**。它是由胃黏膜产生，可刺激胃液、盐酸、及消化酶的分泌。Gastrin还可刺激平滑肌收缩、增加血液循环和胃肠道液体的分泌。