产品名称：Anti-Myeloperoxidase/FITC抗体

Anti-Myeloperoxidase/FITC抗体

产品编号YB1061R-FITC

英文名称Anti-Myeloperoxidase/FITC

中文名称FITC标记的髓过氧化物酶抗中性粒细胞胞质IgG抗体

别    名Myeloperoxidase; MPO; c-ANCA; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN.  

Anti-Myeloperoxidase/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  **学  激酶和磷酸酶  **细胞  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量77kDa

Anti-Myeloperoxidase/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Myeloperoxidase

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Myeloperoxidase/FITC抗体

产品介绍background:

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008].

Function:

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, Anti-Myeloperoxidase/FITC抗体MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Subunit:

Tetramer of two light chains and two heavy chains.

Subcellular Location:

Lysosome.

DISEASE:

Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.

Similarity:

Belongs to the peroxidase family. XPO subfamily.

Database links:

Entrez Gene: 4353 Human

Entrez Gene: 17523 Mouse

Entrez Gene: 303413 Rat

Omim: 606989 Human

SwissProt: P05164 Human

SwissProt: P11247 Mouse

Unigene: 458272 Human

Unigene: 4668 Mouse

Unigene: 47782 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

髓过氧化物酶MPO,作为一种白细胞酶,具有介导炎性反应、调节**应答等多种功能,并可参与**的发**展过程。同时,髓过氧化物酶基因存在基因多态性,也影响机体对**的易感性. 在正常**组织中和各种髓样细胞增生症中，MPO均有较强表达，如：**样细胞、原核细胞、肥大细胞、浆细胞以及各种上皮源性肿瘤和肉瘤等