产品名称：Anti-HSL/LIPE/FITC抗体

Anti-HSL/LIPE/FITC抗体

产品编号YB-0455R-FITC

英文名称Anti-HSL/LIPE/FITC

中文名称FITC标记的***敏感脂肪酶抗体

别    名Hormone sensitive lipase; hormone-sensitive lipase; Hormone sensitive lipase testicular isoform; HSL; LHS; Lipase hormone sensitive; LIPE; Hormone-sensitive lipase; LIPS_HUMAN.  

Anti-HSL/LIPE/FITC抗体

说 明 书100ul  

研究领域心血管  **学  生长因子和**  糖尿病  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Rat, Fruit Fly,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量116kDa

细胞定位细胞膜

Anti-HSL/LIPE/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from rat HSL N-terminus

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-HSL/LIPE/FITC抗体

产品介绍background:

HSL ( hormone- sensitive lipase ) is an enzyme involved in hydrolysis of stored triglycerides and fatty acids; important for regulation of energy homeostasis. It has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids.

Function:

In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.

Subunit:

Interacts with PTRF in the adipocyte cytoplasm.

Subcellular Location:

Cell membrane. Anti-HSL/LIPE/FITC抗体Membrane, caveola. Cytoplasm, cytosol.

Similarity:

Belongs to the 'GDXG' lipolytic enzyme family.

Database links:

Entrez Gene: 3991 Human

Entrez Gene: 16890 Mouse

Entrez Gene: 25330 Rat

Omim: 151750 Human

SwissProt: Q05469 Human

SwissProt: Q6NSL7 Human

SwissProt: P54310 Mouse

SwissProt: P15304 Rat

Unigene: 656980 Human

Unigene: 158548 Mouse

Unigene: 333679 Mouse

Unigene: 10566 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HSL又称：敏感性甘油三酯脂肪酶，在脂肪动员中，脂肪细胞内**敏感性甘油三酯脂肪酶（HSL）起决定性作用，它是脂肪分解的限速酶，称为**敏感性脂肪酶。

肾上腺素、去甲肾上腺素、胰高血糖素等激活HSL促进脂肪动员；胰岛素，前列腺素E及烟酸等抑制HSL，抑制脂肪的动员。