产品名称：Anti-GFRA4/FITC抗体

Anti-GFRA4/FITC抗体

产品编号YB-0168R-FITC

英文名称Anti-GFRA4/FITC

中文名称FITC标记的GDNF家族受体α4抗体 GDNFRα4

别    名Persephin receptor; GDNF family receptor alpha 4; GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR alpha 4; GFR receptor alpha 4; GFR-alpha-4; GFRA4; GFRA4_HUMAN; Glial cell line derived neurotrophic factor family receptor alpha 4; Neurotrophic factor receptor splice variant A (Gfra4 gene); OTTHUMP00000030106; OTTHUMP00000030107.  

Anti-GFRA4/FITC抗体

说 明 书100ul  

研究领域神经生物学  通道蛋白  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量27kDa

Anti-GFRA4/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human GFRA4

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-GFRA4/FITC抗体

产品介绍background:

The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]

Function:

Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

Subcellular Location:

Isoform GFRalpha4a: Cell membrane; Lipid-anchor, GPI-anchor.

Isoform GFRalpha4b: Cell membrane; Lipid-anchor, GPI-anchor.

Isoform GFRalpha4c: Secreted.

Tissue Specificity:

Predominantly expressed in the ***** thyroid gland.Anti-GFRA4/FITC抗体 Low levels also found in fetal adrenal and thyroid glands.

Similarity:

Belongs to the GDNFR family.

Database links:

Entrez Gene: 64096 Human

SwissProt: Q9GZZ7 Human

Unigene: 302025 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Persephin receptor 是一个新的神经营养因子，属于GDNFR家族，调节GDNF诱导的自动磷酸化和RET受体的活性。他在维持神经系统正常生存中起重要作用。主要表达在正常和恶性甲状腺髓细胞。分子量约为30kDa。