产品名称：Anti-GAP43/FITC抗体

Anti-GAP43/FITC抗体

产品编号YB0154R-FITC

英文名称Anti-GAP43/FITC

中文名称FITC标记的神经生长相关蛋白43抗体

别    名Growth Associated Protein-43; Neuromodulin; Axonal membrane protein GAP 43; B-50; F1; GAP 43; Growth Associated Protein 43; Nerve Growth Related Peptide; Neural phosphoprotein B 50; Neuromodulin; GAP-43; pp46; NEUM_HUMAN; Protein F1; QtrA-11580; QtrA-13071.  

Anti-GAP43/FITC抗体

说 明 书100ul  

研究领域肿瘤  **学  神经生物学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量46kDa

Anti-GAP43/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human GAP43 C-terminus

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-GAP43/FITC抗体

产品介绍background:

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:

This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

Subunit:

Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.

Subcellular Location:

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Anti-GAP43/FITC抗体Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.

Post-translational modifications:

Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.

Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2.

Similarity:

Belongs to the neuromodulin family.

Contains 1 IQ domain.

Database links:

Entrez Gene: 2596 Human

Entrez Gene: 14432 Mouse

Entrez Gene: 29423 Rat

GenBank: NP_002036 Human

Omim: 162060 Human

SwissProt: P17677 Human

SwissProt: P06837 Mouse

SwissProt: P07936 Rat

Unigene: 134974 Human

Unigene: 1222 Mouse

Unigene: 10928 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神经生物学相关蛋白（Neurobiology）；神经标志物

GAP43 （Growth associated protein-43）又称作neuromodulin，是一个轴突膜蛋白，是一种神经特异性的蛋白质，参与神经细胞外生长及突触发育形成和神经****。在神经元发育和再生过程中以高水平表达。能调解轴突延伸作用，改变细胞形态。作为细胞内信号，可大大增强与G蛋白偶联的受体转运作用。

神经生长相关蛋白-GAP-43和神经细胞黏附因子(neural cell adhesion molecule,NCAM)与突触可塑性密切相关.GAP-43是一种神经细胞膜上的特异性磷蛋白,在神经发育和再生过程中呈现高表达,被作为突触生长的标志物,有称脊髓生长相关蛋白

GAP-43与CaM结合,参与G蛋白相互作用,神经递质的释放,作用于胞吞/胞吐过程,通过小囊溶合或诱导生长锥和突触前末端的胞吞促进膜扩展,与海马长时程增强密切相关.

神经细胞黏附因子是细胞表面糖蛋白大家族的成员之一,促进轴突生长,对长时记忆的保持有重要影响,同时,GAP-43对其具调节作用，广泛而深入地研究GAP-43意义深远。