产品名称：Anti-GABRA1/GABA A Receptor alpha 1/FITC抗体

Anti-GABRA1/GABA A Receptor alpha 1/FITC抗体

产品编号YB-1232R-FITC

英文名称Anti-GABRA1/GABA A Receptor alpha 1/FITC

中文名称FITC标记的G1氨基丁酸A型受体α1抗体

别    名ECA4; EJM; EJM5; Gaba receptor alpha 1 polypeptide; GABA(A) receptor; GABA(A) receptor subunit alpha 1; GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1; GABRA 1; GABRA1; Gamma aminobutyric acid (GABA) A receptor alpha 1; Gamma aminobutyric acid A receptor alpha 1; Gamma aminobutyric acid receptor subunit alpha 1; Gamma-aminobutyric acid receptor subunit alpha-1; GBRA1_HUMAN.  

Anti-GABRA1/GABA A Receptor alpha 1/FITC抗体

说 明 书100ul  

研究领域**学  神经生物学  信号转导  激酶和磷酸酶  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量52kDa

细胞定位细胞膜

Anti-GABRA1/GABA A Receptor alpha 1/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human GABRA1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-GABRA1/GABA A Receptor alpha 1/FITC抗体

产品介绍background:

This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq].

Function:

Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleepAnti-GABRA1/GABA A Receptor alpha 1/FITC抗体, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen.

Subcellular Location:

Secreted and Cell membrane.

Tissue Specificity:

Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.

Similarity:

Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.

Contains 2 Sushi (CCP/SCR) domains.

Database links:

Entrez Gene: 2554 Human

Entrez Gene: 14394 Mouse

Entrez Gene: 29705 Rat

Omim: 137160 Human

SwissProt: P19150 Chicken

SwissProt: P08219 Cow

SwissProt: P14867 Human

SwissProt: P62812 Mouse

SwissProt: P62813 Rat

Unigene: 175934 Human

Unigene: 439668 Mouse

Unigene: 28463 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GABA是**神经系统主要的抑制性神经递质，而GABA-ARα1是GABA的受体之一,在脑内分布*普遍,α1亚单位与其功能密切相关。通过位于脑内的GABA受体发挥抑制性作用GABA及GABA-ARα1在癫痫、颅脑损伤、神经毒剂中毒等**、损伤和中毒模型中的表达、结合都有改变