产品名称：Anti-FoxP3/FITC抗体

Anti-FoxP3/FITC抗体

产品编号YB-0269R-FITC

英文名称Anti-FoxP3/FITC

中文名称FITC标记的叉头蛋白P3抗体

别    名AIID; AIID; DIETER; DIETER; Forkhead box P3; Forkhead box protein P3; foxp3; foxp3; FOXP3_HUMAN; FOXP3delta7; Immune dysregulation polyendocrinopathy enteropathy X linked; Immunodeficiency polyendocrinopathy enteropathy X linked; IPEX; IPEX; JM2; JM2; MGC141961; MGC141963; OTTHUMP00000025832; OTTHUMP00000025833; OTTHUMP00000226737; PIDX; PIDX; SCURFIN; SCURFIN; XPID; XPID.  

Anti-FoxP3/FITC抗体

说 明 书100ul  

研究领域转录调节因子  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量47kDa

Anti-FoxP3/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human FoxP3

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-FoxP3/FITC抗体

产品介绍background:

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

Function:

Probable transcription factor. Plays a critical role in the control of immune response.

Subunit:

Interacts with IKZF3.

Subcellular Location:

Nucleus (Potential).

Post-translational modifications:

Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Deacetylated by SIRT1.

DISEASE:

Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. Anti-FoxP3/FITC抗体IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.

Similarity:

Contains 1 C2H2-type zinc finger.

Contains 1 fork-head DNA-binding domain.

Database links:

Entrez Gene: 50943 Human

Entrez Gene: 20371 Mouse

Entrez Gene: 317382 Rat

Omim: 300292 Human

SwissProt: Q9BZS1 Human

SwissProt: Q99JB6 Mouse

SwissProt: D3ZKI1 Rat

Unigene: 247700 Human

Unigene: 182291 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

叉头蛋白3(FOXP3)是FOX蛋白家族成员之一,主要为T细胞转录蛋白，主要表达于T细胞+CD4+CD25,并调节该类T细胞的发育和功能.

FOXP3的表达受转化生长因子-β雌**和糖皮质**等调节,通过竞争性抑制活化T细胞核因子的转录活性而发挥作用.自身**性糖尿病患者体内CD4+CD25+T细胞减少,诱导FOXP3的表达或过继转移CD4+CD25+T细胞有可能预防自身**性糖尿病