产品名称：Anti-FRA2/FITC抗体

Anti-FRA2/FITC抗体

产品编号YB1188R-FITC

英文名称Anti-FRA2/FITC

中文名称FITC标记的FRA2/FOSL2抗体

别    名FLJ23306; Fos L2; FOS like antigen 2; Fos related antigen 2; FosL 2; FosL2; FOSL2; FOSL2_HUMAN; FRA 2; fos-related antigen 2.  

Anti-FRA2/FITC抗体

说 明 书100ul  

研究领域肿瘤  信号转导  生长因子和**  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量36kDa

Anti-FRA2/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human FRA2

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-FRA2/FITC抗体

产品介绍background:

Fos and Jun dimerize to form Activator Protein 1 (AP1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13 acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the 'leucine-zipper' motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP1 dependent genes.

Function:

Controls osteoclast survival and size (By similarity). Anti-FRA2/FITC抗体As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity).

Subunit:

Heterodimer

Subcellular Location:

Nuclear

Similarity:

Belongs to the bZIP family. Fos subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Database links:

Entrez Gene: 2355 Human

Entrez Gene: 421416 Chicken

Entrez Gene: 14284 Mouse

Entrez Gene: 25446 Rat

Omim: 601575 Human

SwissProt: P18625 Chicken

SwissProt: P15408 Human

SwissProt: P47930 Mouse

SwissProt: P51145 Rat

Unigene: 220971 Human

Unigene: 596972 Human

Unigene: 24684 Mouse

Unigene: 10962 Rat

Unigene: 163577 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

FOSL2蛋白对细胞因子、生长因子、感染或致癌刺激等生理或病理信号发生应答,调节基因的转录, 参与细胞的增殖、分化等过程. FOSL2在肿瘤形成及发展过程中, 通过促进细胞增殖、抑制分化、促进肿瘤细胞的侵袭和转移等过程发挥作用.