产品名称：Anti-FGL2/FITC抗体

Anti-FGL2/FITC抗体

产品编号YB-0315R-FITC

英文名称Anti-FGL2/FITC

中文名称FITC标记的凝血酶原酶/纤维蛋白原2抗体

别    名Fibroleukin; Cytotoxic T-lymphocyte-specific protein; Fibrinogen-like protein 2; Fibrinogen like protein 2; Prothrombinase; Fibroleukin; pT49; T49; FGL2_HUMAN.  

Anti-FGL2/FITC抗体

说 明 书100ul  

研究领域**学  t-**细胞  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量49kDa

Anti-FGL2/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from Rat FGL2

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-FGL2/FITC抗体

产品介绍background:

FGL2 is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. It may play a role in physiologic functions at mucosal sites. It is constitutively expressed in cytotoxic T-cells. Lack of expression in other lymphoid- and nonlymphoid-derived cell lines suggested that expression of FGL2 may be restricted to lymphocytes. FGL2 is induced via a mechanism involving IFNG and components of the IFNG signaling pathway, including STAT1 and IRF1.

Function:

May play a role in physiologic lymphocyte functions at mucosal sites

Subunit:

Homotetramer; disulfide-linked.

Subcellular Location:

Secreted.

Anti-FGL2/FITC抗体Tissue Specificity:

Constitutively expressed in cytotoxic T-cells.

Similarity:

Contains 1 fibrinogen C-terminal domain.

Database links:

Entrez Gene: 511711 Cow

Entrez Gene: 10875 Human

Entrez Gene: 14190 Mouse

Entrez Gene: 84586 Rat

Omim: 605351 Human

SwissProt: Q14314 Human

SwissProt: P12804 Mouse

Unigene: 520989 Human

Unigene: 292100 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

fgL-2蛋白是新近发现的一种凝血因子，它通过直接激活凝血酶原启动凝血过程。一 系列实验证明，该蛋白在肝细胞坏死中起到重要作用。对乙肝患者肝组织**组织化学染色hfg12在重型乙型肝炎患者高表达。

凝血酶原酶(简称fgl2)蛋白属于纤维蛋白原家族的一员,由活化的巨噬细胞表达,具有凝血酶原酶的活力,能催化凝血酶原转化为凝血酶,启动凝血过程.