产品名称：Anti-Fas Ligand/FITC抗体

Anti-Fas Ligand/FITC抗体

产品编号YB0216R-FITC

英文名称Anti-Fas Ligand/FITC

中文名称FITC标记的FasL抗体

别    名APO1L; Apoptosis (APO 1) antigen ligand 1; Fas-L; Apoptosis antigen ligand 1; APTL; CD178; CD-178; CD 178; CD95L; CD95 ligand; CD95-L; CD95L protein; FAS antigen ligand; Fas L; Fas Ligand; FASL; Fasl; Fas ligand (TNF superfamily member 6); Generalized lymphoproliferative disease; TNF superfamily member 6; TNFSF6; Tumor necrosis factor ligand superfamily member 6; TNFL6_HUMAN; Apoptosis antigen ligand; Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form.  

Anti-Fas Ligand/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  **学  细胞凋亡  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Cow,

产品应用Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量31kDa

细胞定位细胞膜

Anti-Fas Ligand/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Fas Ligand

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Fas Ligand/FITC抗体

产品介绍background:

FasL (CD95L) is a cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T cell mediated apoptosis and in T cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. Homotrimer (Probable). May be released as type II membrane protein. Belongs to the tumor necrosis factor family

Function:

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.

Subunit:

Homotrimer (Probable). Interacts with ARHGAP9, Anti-Fas Ligand/FITC抗体BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.

Subcellular Location:

Cell membrane; Single-pass type II membrane protein. Secreted. Cytoplasmic vesicle lumen. Lysosome lumen. Note=May be released into the extracellular fluid, probably by cleavage form the cell surface. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination.

Post-translational modifications:

N-glycosylated.

The soluble form derives from the membrane form by proteolytic processing.

Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.

Monoubiquitinated.

DISEASE:

Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.

Similarity:

Belongs to the tumor necrosis factor family.

Database links:

Entrez Gene: 356 Human

Entrez Gene: 14103 Mouse

Entrez Gene: 25385 Rat

Omim: 134638 Human

SwissProt: P48023 Human

SwissProt: P41047 Mouse

SwissProt: P36940 Rat

Unigene: 2007 Human

Unigene: 3355 Mouse

Unigene: 9725 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Fas-L 是一个与TNFRSF6/FAS 结合的细胞因子，一个转导凋亡信号到细胞内的一个受体。他可能参与T-细胞调节凋亡细胞毒性和T-细胞的发育。调节凋亡的TNFRSF6/FAS 在外周组织耐受性方面和抗原刺激成熟**细胞**中起作用。FasL诱导物受体TNFRSF6B/DcR3结合调节其作用。

FasL只表达于活化的**细胞，但在小鼠睾丸中可见高表达的FasL;分子量为36-43kDa。属于TNF家族