产品名称：Anti-FAM3B/FITC抗体

Anti-FAM3B/FITC抗体

产品编号YB-0711R-FITC

英文名称Anti-FAM3B/FITC

中文名称FITC标记的胰腺衍生因子抗体

别    名C21orf11; PANDER; Cytokine like protein 2 21; PRED44; PANcreatic DERived factor; Protein FAM3B; Protein FAM3B precursor; Family with sequence similarity 3, member B isoform a; FAM3B_MOUSE.  

Anti-FAM3B/FITC抗体

说 明 书100ul  

研究领域**学  细胞凋亡  糖尿病  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量23kDa

Anti-FAM3B/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human FAM3B

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-FAM3B/FITC抗体

产品介绍background:

FAM3B has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner. [Subcellular Location] Secreted. Note=Localized in discrete vesicular and perinuclear structure. Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. Belongs to the FAM3 family.

Function:

Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.

Subcellular Location:

Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.

Tissue Specificity:

Highly expressed in the pancreas. Anti-FAM3B/FITC抗体Also found in the colon, kidney, prostate, small intestine and testis.

Post-translational modifications:

2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.

O-glycosylated.

Similarity:

Belongs to the FAM3 family.

Database links:

Entrez Gene: 54097 Human

Entrez Gene: 52793 Mouse

Omim: 608617 Human

SwissProt: P58499 Human

SwissProt: Q9D309 Mouse

Unigene: 473877 Human

Unigene: 670704 Human

Unigene: 327932 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胰腺衍生因子（PANcreatic DERived fa*ctor，PANDER）是新发现的一种新型的胰岛细胞因子、由胰岛α细胞和β细胞分泌的一种分泌型细胞因子，与β细胞凋亡密切相关 ，可以诱导胰岛素分泌β细胞，主要用于糖尿病的研究。