产品名称：Anti-EMP-1/FITC抗体

Anti-EMP-1/FITC抗体

产品编号YB-0558R-FITC

英文名称Anti-EMP-1/FITC

中文名称FITC标记的表皮膜蛋白1抗体

别    名CL-20; EMP-1; EMP1; EMP1_HUMAN; Epithelial membrane protein 1; Protein B4B; TMP; Tumor-associated membrane protein.  

Anti-EMP-1/FITC抗体

说 明 书100ul  

研究领域细胞生物  **学  细胞凋亡  细胞膜受体  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量17kDa

细胞定位细胞膜

Anti-EMP-1/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from mouse Emp1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-EMP-1/FITC抗体

产品介绍background:

Epithelial membrane protein-1 (EMP-1) is a four pass transmembrane protein consisting of 160 amino acids. It is a member of a small family of epithelial membrane proteins. EMP-1 is very similar in structure to its close relative, Peripheral Myelin Protein 22 (PMP22). It is most predominantly expressed in tissues of the gastrointestinal tract but has also been found to be a junctional protein in the liver expressed along the intercellular border. EMP-1 directly interacts with the C-terminus of the P2X7 receptor and may be involved in membrane blebbing. EMP-1 may also be an important regulator in cell communication, signaling, and adhesion. When EMP-1 is overexpressed, cell proliferation is inhibited, S phase is arrested and G1 phase is prolonged in esophogeal cancer cells. EMP-1 may play a role in tumorigenesis and has been identified as a biomarker for gefitinib treatment resistance for patients with lung cancer.

Subcellular Location:

Membrane; Multi-pass membrane protein.

Tissue Specificity:

Most prominently found inAnti-EMP-1/FITC抗体 the gastrointestinal tract, skin, lung, and brain but not in liver.

Similarity:

Belongs to the PMP-22/EMP/MP20 family.

Database links:

Entrez Gene: 2012 Human

Omim: 602333 Human

SwissProt: P54849 Human

Unigene: 719042 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

emp-1蛋白主要参与细胞生长发育、细胞增殖、死亡、表皮发育等作用。