产品名称：Anti-EBNA 3A/FITC抗体

Anti-EBNA 3A/FITC抗体

产品编号YB-0820R-FITC

英文名称Anti-EBNA 3A/FITC

中文名称FITC标记的EB病毒核抗原-3A抗体

别    名nuclear antigen EBNA-3; Epstein-Barr nuclear antigen 3; EBV nuclear antigen 3; EBNA-3; Epstein-Barr nuclear antigen 3A; EBV nuclear antigen 3A; EBNA-3A; Epstein Barr Virus; EBV-NA3; EBNA3_EBVG.  

Anti-EBNA 3A/FITC抗体

说 明 书100ul  

研究领域转录调节因子  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 EBV/HHV4

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量103kDa

Anti-EBNA 3A/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from Human herpesvirus 4 EBNA 3A (321-345aa)

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-EBNA 3A/FITC抗体

产品介绍background:

EBNA3A is a latent viral nuclear protein expressed in Epstein Barr Virus (EBV) transformed lymphoblastic cell lines. It is also found in some immunoblastic lymphomas in vivo. This viral nuclear protein is essential for EBV mediated transformation of B lymphocytes. The EBNA3A functions as a transcriptional regulator though the target genes are currently unknown.

Function:

Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.

Subunit:

Interacts with human UCKL1. Interacts with host CTPB1;Anti-EBNA 3A/FITC抗体 this interaction seems important for EBNA3-mediated transcriptional repression. Interacts with host RBPJ.

Subcellular Location:

Host nucleus matrix. Note=Associated with the nuclear matrix.

Similarity:

Belongs to the herpesviridae EBNA-3 family.

Database links:

Entrez Gene: 3783762 EBVG

SwissProt: Q3KST2 EBVG

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

EB病毒核抗原-3（nuclear antigen EBNA-3）是EB病毒编码核蛋白，位于细胞核的新的酶聚合体，主要作为转录调节因子，指导蛋白与蛋白之间相互作用，为核糖核苷酸补救途径的一部分.