产品名称：Anti-EAAT1/FITC抗体

Anti-EAAT1/FITC抗体

产品编号YB1003R-FITC

英文名称Anti-EAAT1/FITC

中文名称FITC标记的胶质细胞谷氨酸运载蛋白1抗体

别    名EA6; EAAT1; Excitatory amino acid transporter 1; FLJ25094; GLAST; GLAST1; Glial high affinity glutamate transporter; High affinity neuronal glutamate transporter; Slc1a3; Sodium dependent glutamate/aspartate transporter; EAA1_HUMAN.  

Anti-EAAT1/FITC抗体

说 明 书100ul  

研究领域神经生物学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量60kDa

细胞定位细胞膜

Anti-EAAT1/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human EAAT1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least tw

Anti-EAAT1/FITC抗体

产品介绍background:

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. [SUBCELLULAR LOCATION] Membrane; Multi-pass membrane protein. [TISSUE SPECIFICITY] Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. [SIMILARITY] Belongs to the sodium: dicarboxylate (SDF) symporter(TC 2.A.23) family.

Function:

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Subunit:

Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. Anti-EAAT1/FITC抗体SLC1A3 subfamily.

Subcellular Location:

Membrane.

Tissue Specificity:

Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.

Post-translational modifications:

Glycosylated.

DISEASE:

Defects in SLC1A3 are the cause of episodic ataxia type 6 (EA6) [MIM:612656]. EA6 is characterized by episodic ataxia, seizures, migraine and alternating hemiplegia.

Similarity:

Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily.

Database links:

Entrez Gene: 6507 Human

Entrez Gene: 20512 Mouse

Entrez Gene: 29483 Rat

Omim: 600111 Human

SwissProt: P43003 Human

SwissProt: P56564 Mouse

SwissProt: P24942 Rat

Unigene: 481918 Human

Unigene: 204834 Mouse

Unigene: 34134 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

EAAT-1主要用于神经胶质细胞的损伤及退变方面的研究.