产品名称：Anti-ARHGAP17/FITC抗体

Anti-ARHGAP17/FITC抗体

产品编号YB2304R-FITC

英文名称Anti-ARHGAP17/FITC

中文名称FITC标记的神经细胞发育相关调控蛋白抗体

别    名ARHGAP17; NADRIN; Neuron associated developmentally regulated protein; Rho GTPase activating protein 17; RhoGAP interacting with CIP4 homologs protein 1; RICH 1; RICH1; WBP15; MST066; MST110; MSTP038; PP367; PP4534; Rho type GTPase activating protein 17; RhoGAP interacting with CIP4 homologs 1; RICH1B.  

Anti-ARHGAP17/FITC抗体

说 明 书100ul  

研究领域**学  神经生物学  信号转导  G蛋白偶联受体  G蛋白信号  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Fruit Fly,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量81kDa

细胞定位细胞膜

Anti-ARHGAP17/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ARHGAP17

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-ARHGAP17/FITC抗体

产品介绍background:

ARHGAP17 is a Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. It specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. RHGAP17 participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.

Function:

Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.

Subunit:

Component of a complex whose core is composed of ARHGAP17, Anti-ARHGAP17/FITC抗体AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with SLC9A3R1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP and SH3KBP1/CIN85.

Subcellular Location:

Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact.

Tissue Specificity:

Ubiquitously expressed. Expressed at higher level in heart and placenta.

Similarity:

Contains 1 BAR domain.

Contains 1 Rho-GAP domain.

Database links:

Entrez Gene: 55114 Human

Entrez Gene: 70497 Mouse

Entrez Gene: 63994 Rat

Omim: 608293 Human

SwissProt: Q68EM7 Human

SwissProt: Q3UIA2 Mouse

SwissProt: Q99N37 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.