产品名称：Anti-MCT1/Malignant T cell amplified sequence 1/FITC抗体

Anti-MCT1/Malignant T cell amplified sequence 1/FITC抗体

产品编号YB1569R-FITC

英文名称Anti-MCT1/Malignant T cell amplified sequence 1/FITC

中文名称FITC标记的单羧酸转运蛋白-1抗体

别    名monocarboxylate transporter 1; Malignant T cell amplified sequence 1; MCT 1; MCT1; MCTS 1; MCTS1; Oncogene MCT 1; Oncogene MCT1; SLC16A1; FLJ36745; HHF7; MCT; MGC44475; monocarboxylate transporter; Monocarboxylate transporter isoform 1; Monocarboxylic acid transporter 1; SLC16A1; SLC16A1 protein; Solute carrier family 16 (monocarboxylic acid transporters) member 1; Solute carrier family 16 member 1 (monocarboxylic acid transporter 1); Solute carrier family 16 member 1; MOT1_HUMAN.  

Anti-MCT1/Malignant T cell amplified sequence 1/FITC抗体

说 明 书100ul  

研究领域**学  转运蛋白  交换蛋白  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,

产品应用Flow-Cyt=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量55kDa

细胞定位细胞膜

Anti-MCT1/Malignant T cell amplified sequence 1/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human MCT1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-MCT1/Malignant T cell amplified sequence 1/FITC抗体

产品介绍background:

The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

Function:

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.

Subcellular Location:

Cell membrane; Multi-pass membrane protein.

Tissue Specificity:

Widely expressed in normal and in cancer cells.

DISEASE:

Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT) [MIM:245340]; also known as erythrocyte lactate transporter defect. Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. Anti-MCT1/Malignant T cell amplified sequence 1/FITC抗体This defect might compromise extreme performance in otherwise healthy individuals.

Defects in SLC16A1 are the cause of familial hyperinsulinemic hypoglycemia type 7 (HHF7) [MIM:610021]; also known as exercise-induced hyperinsulinemic hypoglycemia. HHF7 is a dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load.

Similarity:

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

Database links:

Entrez Gene: 6566 Human

Entrez Gene: 20501 Mouse

Omim: 600682 Human

SwissProt: P53985 Human

SwissProt: P53986 Mouse

Unigene: 75231 Human

Unigene: 9086 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

单羧酸转运蛋白家族是哺乳动物细胞膜上一类重要的跨膜转运蛋白,负责乳酸、短链脂肪酸等单羧酸类化合物的跨膜转运,有促进营养物质吸收、代谢动态的平衡、调节胞内pH值以及参与**输送等多种生物学功能