产品名称：Anti-NAIF1/FITC抗体

Anti-NAIF1/FITC抗体

产品编号YB-0452R-FITC

英文名称Anti-NAIF1/FITC

中文名称FITC标记的核凋亡诱导因子蛋白1

别    名NAIF1 protein; nuclear apoptosis inducing factor 1; CB12-327; 2310007O20Rik; 4933440H19Rik; bA379C10.2; C9orf90; DKFZP762G199; NAIF1; RP11-379C10.2; NAIF1_HUMAN.  

Anti-NAIF1/FITC抗体

说 明 书100ul  

研究领域染色质和核信号  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量35kDa

Anti-NAIF1/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human NAIF1 N-terminus

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-NAIF1/FITC抗体

产品介绍background:

NAIF protein 1 (nuclear apoptosis inducing factor 1; CB12-327; RP-379C10.2) belongs to the NAIF1 family. Apoptosis is a genetically determined cell suicidal pro gram that plays critical roles in many physiological and pathological processes. nuclear apoptosis-inducing factor 1 (NAIF1), overexpression of which induces apoptosis in cells. Human NAIF1 is located on chromosome 9q34.11 and encodes 327 amino acids with a homeodomain-like region and two nuclear localization signals at its N-terminal region. NAIF1 is conserved across diverse species, including human, mouse, crab-eating macaque, dog, chicken and frog, and shares no obvious homology to any known genes or proteins. Northern blot analysis revealed wide expression of NAIF1 mRNA throughout human tissues. NAIF1 was predominantly localized in the nucleus. Overexpression of NAIF1 inhibited cell growth and induced apoptosis. Furthermore,Anti-NAIF1/FITC抗体NAIF1 transfection caused both decreases in mitochondrial membrane potential and caspase-3 activation. In summary, NAIF1 is a nuclear protein that induces apoptosis when overexpressed.

Function:

Induces apoptosis.

Subunit:

Interacts with HARBI1.

Subcellular Location:

Nucleus.

Tissue Specificity:

Widely expressed.

Similarity:

Belongs to the NAIF1 family.

Database links:

Entrez Gene: 510689 Cow

Entrez Gene: 203245 Human

Entrez Gene: 71254 Mouse

Omim: 610673 Human

SwissProt: A7MBH3 Cow

SwissProt: Q9BE21 Cynomolgus Monkey

SwissProt: Q69YI7 Human

SwissProt: Q6PFD7 Mouse

Unigene: 373606 Human

Unigene: 102341 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

NAIF1 protein(CB12-327)是*新发现的大肠癌标志物他抑制NFκB，NFAT，AP-1活性，并诱导细胞调亡。