产品名称：Anti-MTLC/FITC抗体

Anti-MTLC/FITC抗体

产品编号YB-0334R-FITC

英文名称Anti-MTLC/FITC

中文名称FITC标记的致癌基因抗体

别    名myc target 1; Myc target 1; MYCT 1 protein; Myc target in myeloid cells protein 1; Myc target protein 1; 1110020B04Rik; AI225941; AI642973; FLJ21269; MGC156309; MGC156310; Mt-Mc1; MTLC; Mtmc1; MYCT1; MYCT1_HUMAN; Myct1; MTMC1.  

Anti-MTLC/FITC抗体

说 明 书100ul  

研究领域**学  染色质和核信号  转录调节因子  表观遗传学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Dog,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量27kDa

Anti-MTLC/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human MTLC

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-MTLC/FITC抗体

产品介绍background:

MTLC is a 235 amino acid nuclear protein that is thought to regulate certain myc target genes. Downregulated in gastric cancer tissues, MTLC is expressed in the hepatocellular carcinoma cell line, Bel7402. Overexpression of MTLC is thought to influence tumorigenic conversion, promotion of apoptosis genomic instability and inhibition of hematopoietic differentiation. The gene encoding MTLC maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

Function:

May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition oAnti-MTLC/FITC抗体 hematopoietic differentiation.

Subcellular Location:

Nucleus. Note=Expressed in nuclei of hepatocellular carcinoma cell line Bel7402 cells.

Tissue Specificity:

Down-regulated in gastric cancer tissues.

Similarity:

Belongs to the MYCT1 family.

Database links:

Entrez Gene: 80177 Human

Entrez Gene: 68632 Mouse

Entrez Gene: 292264 Rat

SwissProt: Q8N699 Human

SwissProt: Q8R411 Mouse

Unigene: 18160 Human

Unigene: 338242 Mouse

Unigene: 55418 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.