产品名称：Anti-ACVR1B抗体

Cat. Number:

YB6018R

Quantity size:

0.1ml

Concentration:

Anti-ACVR1B抗体1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

[FUNCTION]Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.Anti-ACVR1B抗体 Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.

Also known as:

Anti-ACVR1B抗体Activin A receptor type 1B; Activin A receptor type II like kinase 4; Activin A type 1B receptor; Activin A type IB receptor; Activin receptor like kinase 4; Activin receptor type 1B; Activin receptor type IB; Activin receptor type-1B; Activin receptor-like kinase 4; ACTR IB; ACTR-IB; ACTRIB; ACV1B_HUMAN; ACVR 1B; ACVR1B; ACVRLK 4; ACVRLK4; ALK 4; ALK-4; ALK4; Serine(threonine) protein kinase receptor R2; Serine/threonine-protein kinase receptor R2; SKR 2; SKR2.

Specificity:

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

Anti-ACVR1B抗体WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.YB013Hu01 骨成型蛋白2(BMP2)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2) Homo sapiens (Human)
YB013Mu01 骨成型蛋白2(BMP2)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2) Mus musculus (Mouse)
YB013Po01 骨成型蛋白2(BMP2)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2) Sus scrofa; Porcine (Pig)
YB013Ra01 骨成型蛋白2(BMP2)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2) Rattus norvegicus (Rat)
YB013Rb52 骨成型蛋白2(BMP2)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2) Oryctolagus cuniculus (Rabbit)
YB014Bo01 骨成型蛋白4(BMP4)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) Bos taurus; Bovine (Cattle)
YB014Ca01 骨成型蛋白4(BMP4)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) Canis familiaris; Canine (Dog)
YB014Cp01 骨成型蛋白4(BMP4)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) Capra hircus; Caprine (Goat)
YB014Ga01 骨成型蛋白4(BMP4)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) Chicken (Gallus)
YB014Po01 骨成型蛋白4(BMP4)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) Sus scrofa; Porcine (Pig)
YB014Rb53 骨成型蛋白4(BMP4)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) Oryctolagus cuniculus (Rabbit)
YB015Hu01 骨成型蛋白受体1A(BMPR1A)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein Receptor 1A (BMPR1A) Homo sapiens (Human)
YB015Mu01 骨成型蛋白受体1A(BMPR1A)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein Receptor 1A (BMPR1A) Mus musculus (Mouse)
YB015Ra01 骨成型蛋白受体1A(BMPR1A)多克隆抗体 Polyclonal Antibody to Bone Morphogenetic Protein Receptor 1A (BMPR1A) Rattus norvegicus (Rat)
YB017Bo01 上皮性钙黏附蛋白(CDHE)多克隆抗体 Polyclonal Antibody to Cadherin, Epithelial (CDHE) Bos taurus; Bovine (Cattle)
YB017Ga01 上皮性钙黏附蛋白(CDHE)多克隆抗体 Polyclonal Antibody to Cadherin, Epithelial (CDHE) Chicken (Gallus)
YB017Hu01 上皮性钙黏附蛋白(CDHE)多克隆抗体 Polyclonal Antibody to Cadherin, Epithelial (CDHE) Homo sapiens (Human)
YB017Mu01 上皮性钙黏附蛋白(CDHE)多克隆抗体