产品名称：Anti-ATP1A1/FITC抗体

Anti-ATP1A1/FITC抗体

产品编号YB-9570R-FITC

英文名称Anti-ATP1A1/FITC

中文名称FITC标记的Na+/K+-ATPase α1 钠钾ATP酶α1抗体

别    名alpha 3 Sodium Potassium ATPase ; AT1A1_HUMAN; ATP1A1; Atpa-1; ATPase Na+/K+ transporting alpha 1 polypeptide; BC010319; EC 3.6.3.9; MGC3285; MGC38419; MGC51750; Na K ATPase alpha A catalytic polypeptide; Na K ATPase catalytic subunit alpha A protein; Na(+)/K(+) ATPase 1; Na(+)/K(+) ATPase alpha-1 subunit; Na+/K+ ATPase alpha 1 subunit; Na+/K+ ATPase 1; Nkaa1b; Sodium potassium ATPase alpha 1 polypeptide; Sodium pump 1; Sodium pump subunit alpha-1; Sodium/potassium transporting ATPase alpha 1 chain; Sodium/potassium-transporting ATPase subunit alpha-1.

Anti-ATP1A1/FITC抗体   

说 明 书100ul  

研究领域肿瘤  细胞生物  神经生物学  信号转导  通道蛋白  细胞膜受体  G蛋白偶联受体  新陈代谢  G蛋白信号  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量112kDa

细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ATP1A1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-ATP1A1/FITC抗体

产品介绍background:

The ubiquitously expressed sodium/potassium-ATPase (Na+/K+-ATPase) exists as a oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na+ ions and two K+ ions against their respective electrochemical gradients. As a member of the P-type family of ion motives, Na+/K+-ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport.The Alpha subunit contains the binding sites for ATP and the cations; the glycosylated Beta subunit ensures correct folding and membrane insertion of the Alpha subunits. The small subunit co-localizes with the Alpha subunit in nephron segments, where it increases the affinity of Na+/K+-ATPase for ATP. The Betasubunit, but not the subunit, is essential for normal activity of Na+/K+-ATPase.

Function:

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. Anti-ATP1A1/FITC抗体This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Subunit:

Interacts with SIK1. Composed of three subunits: alpha (catalytic), beta and gamma. Binds the HLA class II histocompatibility antigen, DR1.

Subcellular Location:

Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Post-translational modifications:

Phosphorylation on Tyr-10 modulates pumping activity. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity.

Similarity:

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

Anti-ATP1A1/FITC抗体Database links:

Entrez Gene: 476 Human

Entrez Gene: 11928 Mouse

Entrez Gene: 24211 Rat

Omim: 182310 Human

SwissProt: P05023 Human

SwissProt: Q8VDN2 Mouse

SwissProt: P06685 Rat

Unigene: 371889 Human

Unigene: 280103 Mouse

Unigene: 217534 Rat

Unigene: 2992 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.