产品名称：Anti-ASB7/FITC抗体

Anti-ASB7/FITC抗体

产品编号YB-9134R-FITC

英文名称Anti-ASB7/FITC

中文名称FITC标记的含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族7抗体

别    名Ankyrin repeat and SOCS box containing protein 7; ASB 7; ASB-7; ASB7_HUMAN.

Anti-ASB7/FITC抗体 

说 明 书100ul  

研究领域细胞生物  **学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Horse, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量36kDa

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ASB7

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-ASB7/FITC抗体

产品介绍background:

Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B/C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. ASB-7 (ankyrin repeat and SOCS box-containing 7) is a 318 amino acid protein that contains one SOCS box domain and seven ANK repeats and belongs to the ASB family. Existing as multiple alternatively spliced isoforms, Anti-ASB7/FITC抗体SB-7 functions as a substrate-recognition component of an E3 ubiquitin-protein ligase complex and, working in conjunction with other proteins, plays a role in the ubiquitination and subsequent proteasomal degradation of target proteins.

Function:

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Anti-ASB7/FITC抗体Subunit:

Interacts with CUL5 and RNF7.

Similarity:

Contains 7 ANK repeats.

Contains 1 SOCS box domain.

Database links:

UniProtKB/Swiss-Prot: Q9H672.2

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.