产品名称：Anti-ATAD2/FITC抗体

Anti-ATAD2/FITC抗体

产品编号YB-9110R-FITC

英文名称Anti-ATAD2/FITC

中文名称FITC标记的三磷酸腺苷酶家族蛋白2抗体

别    名 AAA nuclear coregulator cancer-associated protein; ANCCA; Atad2; ATAD2_HUMAN; ATPase family AAA domain containing 2; ATPase family AAA domain containing protein 2; ATPase family AAA domain-containing protein 2.

Anti-ATAD2/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  **学  信号转导  表观遗传学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量158kDa

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ATAD2

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-ATAD2/FITC抗体

产品介绍background:

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

Function:

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

Subunit:

Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol.Anti-ATAD2/FITC抗体 Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro).

Subcellular Location:

Anti-ATAD2/FITC抗体Nucleus

Tissue Specificity:

Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.

Similarity:

Belongs to the AAA ATPase family.

Contains 1 bromo domain.

Database links:

UniProtKB/Swiss-Prot: Q6PL18.1

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.