产品名称：Anti-ATAD3A/FITC抗体

Anti-ATAD3A/FITC抗体

产品编号YB9108R-FITC

英文名称Anti-ATAD3A/FITC

中文名称FITC标记的三磷酸腺苷酶家族蛋白3A抗体

别    名AAA-ATPase TOB3; ATAD3B; ATAD3C; Atad3a; ATPase family AAA domain containing protein 3A; ATPase family AAA domain-containing protein 3; ATPase family, AAA domain containing 3A; FLJ10709; FLJ35514; AAA ATPase TOB3; AAA-TOB3; ATPase family AAA domain containing protein 3B; ATPase family, AAA domain containing 3B; ATPase family, AAA domain containing, member 3B; TOB3; ATD3A_HUMAN; ATAD3A/B/C.

Anti-ATAD3A/FITC抗体

说 明 书100ul  

研究领域细胞生物  **学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Pig, Cow, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量71kDa

细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ATAD3A

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-ATAD3A/FITC抗体生 产 商BIOSS

产品介绍background:

The AAA ATPase family of molecular chaperones are characterized by a highly conserved AAA motif. Composed of 200-250 residues, the AAA domain contains Walker homology sequences and imparts ATPase activity. Members of the AAA ATPase family act as DNA helicases as well as transcription factors and are thought to be involved in several cellular functions such as cell-cycle regulation, protein proteolysis, organelle biogenesis and vesicle-mediated protein transport. Mitochondrial membrane proteins ATAD3A and ATAD3B contribute to the stabilization of nucleoids which are large mitochondrial DNA (mtDNA)-protein complexes. ATAD3A/B may participate in the transformation pathway and the chemosensitivity of oligodendrogliomas. The genes encoding ATAD3A/B/C maps to human chromosome 1, which houses over 3,000 genes and is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.

Function:

Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. Anti-ATAD3A/FITC抗体May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis.

Subunit:

Can form homooligomers. Homodimer formation at the N-terminus may be regulated by ATP and is required for the interaction with the inner surface of the mitochondrial outer membrane and correct mitochondrial homeostasis. Interacts with components of the mitochondrial ribosome and with other proteins involved in mitochondrial RNA metabolism. May also interact with protein involved in lipid metabolism, including STARD9. May interact with FAM210A. Interacts with GADD45GIP1. Interacts with S100B in a Ca(+2)- and Zn(+2)-dependent manner; this interaction probably occurs in the cytosol prior to mitochondrial targeting. S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. Interacts with HSP60/HSPD1. Forms heterooligomers with ATAD3B; this interaction may affect ATAD3A activity.

Subcellular Location:

Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrix, mitochondrion nucleoid. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids.

Anti-ATAD3A/FITC抗体Tissue Specificity:

Overexpressed in lung adenocarcinomas (at protein level).

Similarity:

Belongs to the AAA ATPase family.

Database links:

UniProtKB/Swiss-Prot: Q9NVI7.2

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.