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Anti-alpha 2 Macroglobulin/FITC抗体
产品编号YB9505R-FITC
英文名称Anti-alpha 2 Macroglobulin/FITC
中文名称FITC标记的α2巨球蛋白(α-2M)抗体
别 名A2M; A2MG_HUMAN; Alpha 2 M; Alpha 2M; Alpha-2-M; Alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; DKFZp779B086; FWP007; S863 7.
Anti-alpha 2 Macroglobulin/FITC抗体
说 明 书100ul
研究领域细胞生物 **学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,
产品应用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量160kDa
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human alpha 2 Macroglobulin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-alpha 2 Macroglobulin/FITC抗体
产品介绍background:
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008].
Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases.Anti-alpha 2 Macroglobulin/FITC抗体 When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Subunit:
Homotetramer; disulfide-linked.
Subcellular Location:
Secreted
Tissue Specificity:
Secreted in plasma
Similarity:
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Anti-alpha 2 Macroglobulin/FITC抗体Database links:
Entrez Gene: 2 Human
Entrez Gene: 232345 Mouse
Entrez Gene: 24153 Rat
Omim: 103950 Human
SwissProt: P01023 Human
SwissProt: Q61838 Mouse
SwissProt: P06238 Rat
Unigene: 212838 Human
Unigene: 30151 Mouse
Unigene: 225884 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.