产品名称：Anti-ANKRD54/FITC抗体

Anti-ANKRD54/FITC抗体

产品编号YB-8309R-FITC

英文名称Anti-ANKRD54/FITC

中文名称FITC标记的锚蛋白重复域54抗体

别    名Ankrd54; ankyrin repeat domain 54; ankyrin repeat domain 54; Ankyrin repeat domain-containing protein 54; ANR54_HUMAN; LIAR.

Anti-ANKRD54/FITC抗体

说 明 书100ul  

研究领域细胞生物  **学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量32kDa

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ANKRD54

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-ANKRD54/FITC抗体

产品介绍background:

ANKRD54 is a 300 amino acid protein that contains four ankyrin repeats and is expressed as two alternatively spliced isoforms. The gene encoding human ANKRD54 maps to chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia chromosome and the subsequent production of the novel fusion protein BCR-Abl, Anti-ANKRD54/FITC抗体a potent cell proliferation activator found in several types of leukemias.

Function:

Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.

Subunit:

Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN (By similarity). Forms a multiprotein complex with LYN and HCLS1. Interacts with TSN2, VAV1, DBNL AND LASP1.

Subcellular Location:

Nucleus. Cytoplasm. Midbody. Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation.

Similarity:

Contains 4 ANK repeats.

Anti-ANKRD54/FITC抗体Database links:

Entrez Gene: 129138 Human

Entrez Gene: 223690 Mouse

Entrez Gene: 362957 Rat

Omim: 613383 Human

SwissProt: Q6NXT1 Human

SwissProt: Q91WK7 Mouse

SwissProt: Q566C8 Rat

Unigene: 135259 Human

Unigene: 24262 Mous

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.