产品名称：Anti-ANKRD1/FITC抗体

Anti-ANKRD1/FITC抗体

产品编号YB-8074R-FITC

英文名称Anti-ANKRD1/FITC

中文名称FITC标记的心肌锚蛋白重复结构域1抗体

别    名ALRP; ANKR1_HUMAN; ANKRD 1; ANKRD1; Ankyrin repeat domain 1 (cardiac muscle); Ankyrin repeat domain containing protein 1; Ankyrin repeat domain-containing protein 1; C 193; C193; Cardiac ankyrin repeat protein; CARP; CVARP; Cytokine inducible nuclear protein; Cytokine-inducible gene C-193 protein; Cytokine-inducible nuclear protein; HA1A2; Liver ankyrin repeat domain 1; MCARP.

Anti-ANKRD1/FITC抗体

说 明 书100ul  

研究领域肿瘤  心血管  细胞生物  **学  信号转导  转录调节因子  表观遗传学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量36kDa

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ANKRD1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-ANKRD1/FITC抗体

产品介绍background:

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.

Function:

May play an important role in endothelial cell activation.Anti-ANKRD1/FITC抗体 May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.

Subunit:

Interacts with YBX1 (By similarity). Interacts with TTN/titin.

Subcellular Location:

Nucleus.

Tissue Specificity:

Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.

DISEASE:

Defects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR) . TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births.

Similarity:

Contains 5 ANK repeats.

Anti-ANKRD1/FITC抗体Database links:

Entrez Gene: 27063 Human

Entrez Gene: 107765 Mouse

Entrez Gene: 27064 Rat

Omim: 609599 Human

SwissProt: Q15327 Human

SwissProt: Q9CR42 Mouse

SwissProt: Q8R560 Rat

Unigene: 448589 Human

Unigene: 10279 Mouse

Unigene: 3789 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.