产品名称：Anti-AMN1/FITC抗体

Anti-AMN1/FITC抗体

产品编号YB-7960R-FITC

英文名称Anti-AMN1/FITC

中文名称FITC标记的细胞核重定位及纺锤体检查点蛋白AMN1抗体

别    名AMN1; AMN1_HUMAN; Antagonist of mitotic exit network 1 homolog; Protein AMN1 homolog.

Anti-AMN1/FITC抗体

说 明 书100ul  

研究领域细胞生物  **学  染色质和核信号  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量28kDa

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human AMN1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-AMN1/FITC抗体

产品介绍background:

AMN1 is a 258 amino acid protein belonging to the AMN1 family. Encoded by a gene that maps to human chromosome 12p11.21, AMN1 contains twelve degenerate leucine-rich repeat (LRR) motifs and modulates Ste12 binding to promoters of multiple genes. As a daughter cell-specific protein, AMN1 inhibits ELL function to deactivate the mitotic exit state and reset the cell cycle in G1. AMN1 does not halt mitotic exit, but turns it off afterward. Induced by ELL after exit activation,Anti-AMN1/FITC抗体 AMN1 disrupts TEM1-Cdc15 interaction by competing with Cdc15 for TEM1 binding and by facilitating inactivation of Cdc14. Defects in AMN1 can result in disruption of both the spindle assembly and nuclear orientation checkpoints. AMN1 may also mediate gene activity and phenotypic diversity.

Similarity:

Belongs to the AMN1 family.

Database links:

Entrez Gene: 524465 Cow

Entrez Gene: 196394 Human

Entrez Gene: 302032 Rat

Anti-AMN1/FITC抗体SwissProt: Q32L08 Cow

SwissProt: Q8IY45 Human

SwissProt: Q5U201 Rat

Unigene: 585084 Human

Unigene: 591146 Human

Unigene: 104358 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.