产品名称：Anti-AFF4/FITC抗体

Anti-AFF4/FITC抗体

产品编号YB-7886R-FITC

英文名称Anti-AFF4/FITC

中文名称FITC标记的**细胞相关AF4样蛋白抗体

别    名Alf4; Laf4; MGC107469; AF4/FMR2 family member 4; AF5Q31; ALL1 fused gene from chromosome 5q31; HSPC092; Lymphoid nuclear protein related to AF4 like; Major CDK9 elongation factor associated protein; MCEF; RP23-226J16.7; AFF4_HUMAN.

Anti-AFF4/FITC抗体 

说 明 书100ul  

研究领域细胞生物  信号转导  细胞周期蛋白  转录调节因子  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量127kDa

性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human AFF4

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-AFF4/FITC抗体

产品介绍background:

May play a role in transcriptional regulation. Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb).

Function:

May play a role in transcriptional regulation.

Subunit:

Component of the cyclin-dependent kinase pair(CDK9/cyclin-T1) complex, also called positive transcriptionelongation factor b (P-TEFb).

Subcellular Location:

Nucleus.

Tissue Specificity:

Ubiquitously expressed. Strongly expressed inheart, placenta, skeletal muscle, pancreas and to a lower extent inbrain.

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR. [DISEASE] Note=A chromosomal aberration involving AFF4 is found inacute lymphoblastic leukemia (ALL). Anti-AFF4/FITC抗体Insertion ins(5;11)(q31;q13q23)that forms a MLL-AFF4 fusion protein.

Similarity:

Belongs to the AF4 family.

Database links:

Entrez Gene: 27125 Human

Entrez Gene: 93736 Mouse

Entrez Gene: 303132 Rat

Omim: 604417 Human

SwissProt: Q9UHB7 Human

SwissProt: Q9ESC8 Mouse

Anti-AFF4/FITC抗体Unigene: 519313 Human

Unigene: 395281 Mouse

Unigene: 17594 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.