- 入驻时间: 2015-11-06
- 联系人:顾磊
- 电话:021-60514606
-
联系时,请说明易展网看到的
- Email:shybio@126.com
Anti-AGTRAP/FITC抗体
产品编号YB-7642R-FITC
英文名称Anti-AGTRAP/FITC
中文名称FITC标记的血管紧张素Ⅱ受体相关蛋白抗体
别 名Angiotensin Ⅱ receptor associated protein; Angiotensin Ⅱ type I receptor associated protein; ATI receptor associated protein; ATRAP; MGC29646; Type 1 angiotensin Ⅱ receptor associated protein; ATRAP_HUMAN.
Anti-AGTRAP/FITC抗体
说 明 书100ul
研究领域心血管 细胞生物 信号转导 G蛋白偶联受体
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Horse, Rabbit, Sheep,
产品应用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量17kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human AGTRAP
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-AGTRAP/FITC抗体
产品介绍background:
AGTRAP (Angiotensin II receptor-associated protein) interacts with the angiotensin II type 1 receptor and negatively regulates type 1 angiotensin II receptor-mediated signaling, by regulating receptor internalisation as well as mechanisms of receptor desensitization such as phosphorylation.
Function:
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Subunit:
Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1.
Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Anti-AGTRAP/FITC抗体Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
Tissue Specificity:
Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
Anti-AGTRAP/FITC抗体Database links:
Entrez Gene: 57085 Human
Omim: 608729 Human
SwissProt: Q6RW13 Human
Unigene: 464438 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.