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Anti-ABC2/FITC抗体
产品编号YB-6515R-FITC
英文名称Anti-ABC2/FITC
中文名称FITC标记的乳腺癌增强蛋白2抗体
别 名ABC 2; ABC2; ABC-2; Amplified in breast cancer gene 2 protein; Chromosome 17 open reading; chromosome 17 open reading frame 71; Protein smg 8 homolog; protein SMG8; SMG8; SMG8 protein; SMG8_HUMAN.
Anti-ABC2/FITC抗体
说 明 书100ul
研究领域肿瘤 肿瘤细胞生物标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产品应用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量110kDa
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ABC2/C17orf71 (744-790aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-ABC2/FITC抗体
产品介绍background:
C17orf71 belongs to the UPF0487 family. There are 3 isoforms produced by alternative splicing.Positive control;Human Anaplastic Thyroid Carcinoma, Human Breast Carcinoma.
Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.
Subunit:
Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain.Anti-ABC2/FITC抗体 Forms heterodimers with SMG9; this assembly form may represent a SMG1C intermediate form.
Subcellular Location:
Phosphorylated by SMG1
Post-translational modifications:
Phosphorylated by SMG1.
Anti-ABC2/FITC抗体Similarity:
Belongs to the SMG8 family.
Database links:
UniProtKB/Swiss-Prot: Q8ND04.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.