产品名称：Anti-laminin/FITC抗体

Anti-laminin/FITC抗体

产品编号YB0821R-FITC

英文名称Anti-laminin/FITC

中文名称FITC标记的层粘连蛋白抗体

别    名LAMA 1; LAMA; LAMA1; LAMB1; Laminin A chain; Laminin alpha 1; Laminin alpha 1 chain; Laminin B1 chain; Laminin subunit beta 1.  

Anti-laminin/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  **学  神经生物学  信号转导  细胞凋亡  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Cow,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量131kDa

细胞定位细胞膜

Anti-laminin/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human laminin

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-laminin/FITC抗体

产品介绍background:

laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies.

Function:

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Subcellular Location:

Secreted > extracellular space > extracellular matrix > basement membrane.

Tissue Specificity:

Broadly expressed in: skin,Anti-laminin/FITC抗体heart, lung, and the reproductive tracts.

Similarity:

Contains 11 laminin EGF-like domains.

Contains 1 laminin IV type A domain.

Contains 1 laminin N-terminal domain.

Database links:

Entrez Gene: 10319 Human

Entrez Gene: 284217 Human

Entrez Gene: 3908 Human

Entrez Gene: 3912 Human

Entrez Gene: 3913 Human

Entrez Gene: 3915 Human

Entrez Gene: 3918 Human

Entrez Gene: 16772 Mouse

Entrez Gene: 316758 Rat

Omim: 150320 Human

SwissProt: P07942 Human

SwissProt: P24043 Human

SwissProt: P25391 Human

SwissProt: P55268 Human

SwissProt: Q9Y6N6 Human

SwissProt: P19137 Mouse

SwissProt: Q9R0B6 Mouse

Unigene: 201805 Human

Unigene: 270364 Human

Unigene: 302362 Mouse

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

层粘连蛋白主要存在于基膜(basal lamina)结构中，是基膜所特有的非胶原糖蛋白。

层粘连蛋白在细胞发育过程中刺激细胞粘着、细胞运动。LN能够刺激胚胎中神经轴的生长,并促进成年动物的神经损伤后重生长和再生。如同纤粘连蛋白,细胞外的LN能够影响细胞的生长、迁移和分化。LN在原生殖细胞的迁移中起关键作用。

层粘连蛋白是细胞外基底膜的主要组成部分，分布于基底膜和细胞外基质内、成纤维细胞、内皮细胞和平滑肌细胞分泌层粘连蛋白。肿瘤的浸润和转移与其遭到破坏相关。该抗体可用于标记基底膜，有助于观察肿瘤周围基底膜的分布及其改变，间接提示该肿瘤的分化程度和浸润情况。