产品名称：Anti-glypican 3/FITC抗体

Anti-glypican 3/FITC抗体

产品编号YB-1112R-FITC

英文名称Anti-glypican 3/FITC

中文名称FITC标记的磷脂酰基醇蛋白聚糖-3抗体

别    名glypican3; glypican-3; GPC3; Intestinal protein OCI-5; GTR2-2; MXR7; Intestinal protein OCI-5; GPC3_HUMAN; Secreted glypican-3.  

Anti-glypican 3/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  **学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量65kDa

细胞定位细胞膜

Anti-glypican 3/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human glypican

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-glypican 3/FITC抗体

产品介绍background:

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Function:

Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Anti-glypican 3/FITC抗体May regulate growth and tumor predisposition.

Subcellular Location:

Cell membrane and Secreted, extracellular space.

Tissue Specificity:

Highly expressed in lung, liver and kidney.

DISEASE:

Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1) [MIM:312870]; also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.

Similarity:

Belongs to the glypican family.

Database links:

Entrez Gene: 2719 Human

Entrez Gene: 14734 Mouse

Entrez Gene: 25236 Rat

Omim: 300037 Human

SwissProt: P51654 Human

SwissProt: Q8CFZ4 Mouse

SwissProt: P13265 Rat

Unigene: 644108 Human

Unigene: 22515 Mouse

Unigene: 9717 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GPC-3磷脂酰基醇蛋白聚糖-3是一种硫酸类肝素蛋白多糖，GPC-3在不同的组织中具有不同的生物学功能，甚至起着完全不同的作用，可能与肿瘤组织类型、发病机制等密切相关．GPC3在绝大多数HCC(肝细胞癌)患者有表达。