产品名称：Anti-GPA33/FITC抗体

Anti-GPA33/FITC抗体

产品编号bs-1226R-FITC

英文名称Anti-GPA33/FITC

中文名称FITC标记的糖蛋白A33抗体

别    名Cell surface A33 antigen precursor; A33; Cell surface A33 antigen; Gpa33; GPA33_HUMAN; Transmembrane glycoprotein A33; Glycoprotein A33 (transmembrane); MGC129986; MGC129987; glycoprotein A33 transmembrane.  

Anti-GPA33/FITC抗体

说 明 书100ul  

研究领域肿瘤  **学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量33kDa

Anti-GPA33/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human GPA33 C-terminus

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-GPA33/FITC抗体

产品介绍background:

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]

Function:

May play a role in cell-cell recognition and signaling.

Subcellular Location:

Membrane; Single-pass type I membrane protein.

Tissue Specificity:

Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.

Post-translational modifications:

N-glycosylated, contains approximately 8 kDa of N-linked carbohydrate.

Anti-GPA33/FITC抗体Palmitoylated.

Similarity:

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 10223 Human

Omim: 602171 Human

SwissProt: Q99795 Human

Unigene: 651244 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GPA33是胃肠道上皮细胞特异性表达的跨膜糖蛋白,在95％以上的大肠癌、63％的胃癌和50％的胰腺癌中表达。