产品名称：Anti-FOS B/FITC抗体

Anti-FOS B/FITC抗体

产品编号YB-1170R-FITC

英文名称Anti-FOS B/FITC

中文名称FITC标记的FosB蛋白抗体

别    名FBJ murine osteosarcoma viral oncogene homolog B; FOS B; FOS-B; FBJ osteosarcoma oncogene B; fosB; G0/G1 switch regulatory protein 3; FosB; G0/G1 switch regulatory protein 3; G0S3; GOS3; GOS 3; GOS B; GOSB; MGC42291; Oncogene FOS B; Oncogene FOSB; Protein fos B; Protein fosB; DKFZp686C0818; FOSB_HUMAN.  

Anti-FOS B/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  **学  染色质和核信号  转录调节因子  表观遗传学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,

产品应用ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量36kDa

Anti-FOS B/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human FOS B

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-FOS B/FITC抗体

产品介绍background:

Cellular oncogenes, or proto-oncogenes, play pivotal roles in cellular communication pathways that regulate normal growth, development and differentiation. The cellular oncogene families fos and jun encode nuclear proteins that can function as transcription factors. The fos family of nuclear oncogenes encode cFos, Fos B, (fos-related antigen) Fra 1, and Fra 2. Also named as DKFZp686C0818; FBJ murine osteosarcoma viral oncogene homolog B; FosB; G0/G1 switch regulatory protein 3; G0S3; GOS3; GOSB; MGC42291; Oncogene FOS B; Protein fosB.

Function:

FosB interacts with Jun proteins enhancing their DNA binding activity.

Subunit:

Heterodimer.

Subcellular Location:

Nucleus.

Similarity:

Anti-FOS B/FITC抗体Belongs to the bZIP family. Fos subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Database links:

Entrez Gene: 2354 Human

Entrez Gene: 100360880 Rat

Omim: 164772 Human

SwissProt: P53539 Human

Unigene: 590958 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

转录调节因子（Transcriptin Regulators）

FOS B属于转录因子AP-1家族;FosB是一种转录因子，表达后能在脑内维持数周甚至几个月。长期**滥用能引起伏核内FosB表达稳定地增加，表明FosB的表达可能是**成瘾的分子转换机制，是当今**成瘾研究中*受重视的转录因子