产品名称：Anti-p57 Kip2/Cdkn1c/FITC抗体

Anti-p57 Kip2/Cdkn1c/FITC抗体

产品编号YB0538R-FITC

英文名称Anti-p57 Kip2/Cdkn1c/FITC

中文名称FITC标记的周期蛋白依赖激酶抑制因子1C抗体

别    名Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; KIP 2; KIP2; p57; p57 Kip2; p57 Kip 2; p57Kip2; WBS; IMAGE; CDN1C_HUMAN.  

Anti-p57 Kip2/Cdkn1c/FITC抗体

说 明 书100ul  

研究领域肿瘤  细胞生物  细胞周期蛋白  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Cow, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量35kDa

Anti-p57 Kip2/Cdkn1c/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human Cdkn1c (291-343aa)

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-p57 Kip2/Cdkn1c/FITC抗体

产品介绍background:

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].

Function:

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

Subunit:

Interacts with PCNA.

Subcellular Location:

Nucleus.

Tissue Specificity:

Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.

DISEASE:

Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.

Defects in CDKN1C are the cause of intrauterine growth retardation,Anti-p57 Kip2/Cdkn1c/FITC抗体 metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies (IMAGE) [MIM:614732]. A rare condition characterized by intrauterine growth restriction, metaphyseal dysplasia, congenital adrenal hypoplasia, and genital anomalies. Patients with this condition may present shortly after birth with severe adrenal insufficiency, which can be life-threatening if not recognized early and commenced on steroid replacement therapy. Other reported features in this condition include, hypercalciuria and/or hypercalcemia, craniosynostosis, cleft palate, and scoliosis.

Note=Defects in CDKN1C are involved in tumor formation.

Similarity:

Belongs to the CDI family.

Database links:

Entrez Gene: 1028 Human

Entrez Gene: 12577 Mouse

Entrez Gene: 246060 Rat

Omim: 600856 Human

SwissProt: P49918 Human

SwissProt: P49919 Mouse

SwissProt: E9PTV7 Rat

SwissProt: Q69DC0 Rat

Unigene: 106070 Human

Unigene: 168789 Mouse

Unigene: 162507 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

p57 Kip-2调控周期蛋白依赖蛋白激酶、G1 期, 是细胞周期蛋白依赖性激酶(CDK)的抑制蛋白。它通过调控细胞周期进程，参与肿瘤细胞的增殖、分化与凋亡。在多种肿瘤中均发现p57,kip2表达异常，在某些肿瘤中是一种独立的预后因素，与肿瘤的发生、发展及预后有着密切关系