产品名称：Anti-MASH1/FITC抗体

Anti-MASH1/FITC抗体

产品编号YB-1155R-FITC

英文名称Anti-MASH1/FITC

中文名称FITC标记的神经母细胞特异性转移因子抗体

别    名Achaete scute complex homolog 1; ASCL1; MASH1/Achaete-scute homolog 1; Achaete scute complex homolog like 1; Achaete scute complex homologue 1; Achaete scute complex homologue like 1; Ascl 1; Ascl1; Ash 1; Ash1; Hash 1;Hash1; Mammalian achaete scute homolog 1; Mammalian achaete scute homologue 1; Mash 1; Mash1; Achaete-scute homolog 1; ASCL1_HUMAN; ASH-1; hASH1; Class A basic helix-loop-helix protein 46; bHLHa46.  

Anti-MASH1/FITC抗体

说 明 书100ul  

研究领域神经生物学  信号转导  表观遗传学  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Human, Mouse, Rat, Cow, Sheep,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量26kDa

Anti-MASH1/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human ASCL1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-MASH1/FITC抗体

产品介绍background:

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]

Function:

Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5'-CANNTG-3').

Subunit:

Efficient DNA binding requires dimerizationAnti-MASH1/FITC抗体 with another bHLH protein. Forms a heterodimer with TCF3.

Subcellular Location:

Nucleus (Probable).

Similarity:

Contains 1 basic helix-loop-helix (bHLH) domain.

Database links:

Entrez Gene: 429 Human

Entrez Gene: 17172 Mouse

Entrez Gene: 64186 Rat

Omim: 100790 Human

SwissProt: P50553 Human

SwissProt: Q02067 Mouse

SwissProt: P19359 Rat

Unigene: 703025 Human

Unigene: 136217 Mouse

Unigene: 32936 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ASCL1/ASH1是一种神经母细胞特异性转移因子,可以促进细胞向一定方向分化但却抑制了*终的分化环节,造成细胞停留于不成熟阶段.