胶质细胞系源性神经营养因子受体α2抗体
规格：1mg/1ml
英文名： GDNF Receptor alpha 2
别名： GDNF family receptor alpha-2; GDNF Receptor α2; GDNF receptor beta; GDNFR beta; GDNFR-beta; GDNFRB; GFR alpha 2; GFRA 2; GFRA2; GFR alpha-2; Glial cell line derived neurotrophic factor family receptor
分子量： 47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GDNF Rec
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
胶质细胞系源性神经营养因子受体α2抗体细胞定位：细胞膜
产品介绍：background: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. 胶质细胞系源性神经营养因子受体α2抗体This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. Members of the glial cell line-derived neurotrophic factor(GDNF) family, including GDNF and neurturin (NTN),play key roles in the control of vertebrate neuron survivaland differentiation. Physiological responses to NTN requirethe presence of a novel glycosylphosphadidylinositollinked protein NTNRa, which is a cell surface receptor forNTN. The cDNAs encoding NTNRa from human, rat,chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2)or TGF-b-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently. GFRa-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa-2, and the Ret PTK form a complex to transduce NTN signal andto mediate NTN function. Function: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Isoform 1 is found in both brain and placenta. Similarity: Belongs to the GDNFR family. Gene ID: 2675 Database links:胶质细胞系源性神经营养因子受体α2抗体 Entrez Gene: 2675 Human Entrez Gene: 14586 Mouse Entrez Gene: 25136 Rat Omim: 601956 Human SwissProt: O00451 Human SwissProt: O08842 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神经生物学相关蛋白（Neurobiology） 胶质细胞源性神经营养因子(GDNF)是TGF-β家族的一个新亚族，该亚族还有新发现的三个成员：Neurturin(NTN)、Persephin(PSP)和Artemin(ART)，它们均不程度地对多巴胺神经元、脊髓前角运动神经元、背根神经节、颈上神经节以及肾等非神经元细胞都具有生长促进作用。研究表明胶质细胞系源性神经营养因子,主要用于PD的研究。 GDNF的受体是多成分的复合物，它是由固定于质膜外层的糖基磷脂酰肌醇(GPI)被称为GDNFRα和酪氨酸激酶RET蛋白组成。GDNFRα为其配体结合亚单位，而RET则是GDNF的功能性受体亚单位，即GDNF特异地结合于其受体的GDNFRα上，再激活RET的酪氨酸磷酸化传导其信号，影响细胞的活性，发挥其生物学效应。目前，又克隆出了人与大鼠的GDNFRβ序列，与GDNPRα具有47％的同源性。GDNFRβ mRNA在脊髓、DRG和发育中的周围神经上也均有表达。
胶质细胞系源性神经营养因子受体α2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 神经生物学 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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