P物质受体抗体
规格：1mg/1ml
英文名： Neurokinin 1 Receptor
别名： Neurokinin 1; Neurokinin 1 Receptor; NK 1 receptor; NK 1R; NK1 receptor; NK-1R; NK1R; NKIR; SPR; Substance P receptor; TAC 1R; TAC1R; Tachykinin 1 receptor; Tachykinin receptor 1; Tachykinin receptor
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SPR
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig, G
细胞定位：细胞膜
P物质受体抗体产品介绍：background: This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008] Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. Subunit: Interacts with ARRB1 Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: P物质受体抗体Belongs to the G-protein coupled receptor 1 family. Gene ID: 6869 Database links: Entrez Gene: 6869 Human Entrez Gene: 21336 Mouse Entrez Gene: 24807 Rat Omim: 162323 Human SwissProt: P25103 Human SwissProt: P30548 Mouse SwissProt: P14600 Rat Unigene: 633301 Human Unigene: 8055 Mouse Unigene: 89609 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 此抗体与大、小鼠、及豚鼠均有交叉反应。P物质是由11个氨基酸组成的多肽，主要分布于感觉神经纤维、后根神经节和脊髓后角，作为重要的神经递质或调制因子参与伤害性刺激的传递，该递质与突触后膜上P物质受体结合，将痛冲动传入**，产生疼痛反应。P物质受体抗体 P物质与神经源性炎症、瘙痒及疼痛的产生有关，通过刺激肥大细胞释放组织胺、缓激肽及前列腺素等致炎、致敏、致痛物质，引起一系列病理反应，P物质除作为伤害性信息的信使外，本身又为炎症介质。
P物质受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid