转移生长因子α抗体
规格：1mg/1ml
英文名： TGF alpha
别名： EGF like TGF; ETGF; TFGA; TGF A; TGF type 1; TGFA; Transforming growth factor alpha; Transforming growth factor alpha precursor; Wa1; Waved 1; TGFA_HUMAN.
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TGF-alph
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
转移生长因子α抗体细胞定位：细胞膜 细胞外基质 分泌型蛋白
产品介绍：background: This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar (By similarity). Inhibitor of acid secretion. Inhibitor of aminopyrine uptake in parietal cells (in vitro). Subunit: Interacts with the PDZ domains of MAGI3, 转移生长因子α抗体SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2. Subcellular Location: Transforming growth factor alpha: Secreted, extracellular space. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. Similarity: Contains 1 EGF-like domain. Gene ID: 转移生长因子α抗体7039 Database links: Entrez Gene: 403431 Dog Entrez Gene: 7039 Human Entrez Gene: 21802 Mouse Entrez Gene: 24827 Rat Omim: 190170 Human SwissProt: P01135 Human SwissProt: P48030 Mouse SwissProt: P01134 Rat Unigene: 170009 Human Unigene: 137222 Mouse Unigene: 9952 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 生长因子和** TGFα是一个强有力的只有丝分裂多肽,主要由恶性肿瘤产生。
转移生长因子α抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 信号转导 生长因子和** 细胞因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit