磷酸化生肌决定因子Myf5抗体
规格：1mg/1ml
英文名： phospho-MYF5 (phospho Ser49)
别名： Myf5 (phospho S49); Myf5 (phospho Ser49); p-Myf5(phospho S49); p-Myf5(phospho Ser49); Myf-5 bHLHc2; Class C basic helix loop helix protein 2; Class C basic helix-loop-helix protein 2; Myf 5; Myf-5; My
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Horse,
细胞定位：细胞核
磷酸化生肌决定因子Myf5抗体产品介绍：background: Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development include Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Of interest, most muscle cells express either Myo D or Myf-5 in the committed state, but when induced to differentiate, all turn on expression of myogenin. Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes. Function: Involved in muscle differentiation (myogenic factor).磷酸化生肌决定因子Myf5抗体 Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Subcellular Location: Nucleus. Similarity: Contains 1 bHLH (basic helix-loop-helix) domain. Database links: UniProtKB/Swiss-Prot: P13349.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. yf5是MyoD基因家族的一员，该家族的共同结构特点是具有1个保守的中央蛋白基序(motif)，磷酸化生肌决定因子Myf5抗体大小为80个氨基酸，称为碱性螺旋-环-螺旋(bHLH)，bHLH高度保守，其中Basic结构是HLH螺旋结构的延伸，也是这一家族蛋白与DNA相互作用的区域，而HLH螺旋结构则是与其他因子相互作用的位点，即调控的重要区域。 生肌决定因子(MyoD)基因家族控制着肌细胞的增殖和分化，与肌纤维的数量、大小有着密切的关系，因而对肉质和风味有非常重要的作用，MyoD基因家族可编码4种不同的转录因子，分别为MyoD(Myf3)、Myogenin(MyoG)、Myf5、Myf6或MRF4，它们各自或协同控制着骨骼肌生成方面的关键调节因子。
磷酸化生肌决定因子Myf5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 发育生物学 信号转导 干细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid