驱动蛋白样蛋白1抗体
规格：1mg/1ml
英文名： KIF11
别名： HKSP; KIF11; kinesin family member 11; Kinesin like protein 1; Kinesin like spindle protein HKSP; KNSL1;Eg5; Thyroid receptor interacting protein 5; TRIP5; KIF11_HUMAN.
分子量： 120kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KIF11/Eg
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
驱动蛋白样蛋白1抗体产品介绍：background: Eg5 is a motor protein that belongs to the kinesin-like family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. Function: Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays. Subunit: Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts (via C-terminus) with the kinase NEK6 in both interphase and mitosis. Subcellular Location: 驱动蛋白样蛋白1抗体Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Post-translational modifications: Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). Phosphorylated upon DNA damage, probably by ATM or ATR. A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6驱动蛋白样蛋白1抗体 during mitosis; phosphorylation is required for mitotic function. Similarity: Belongs to the kinesin-like protein family. BimC subfamily. Contains 1 kinesin-motor domain. Database links: UniProtKB/Swiss-Prot: P52732.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
驱动蛋白样蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 细胞骨架 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid